產(chǎn)品詳情
簡單介紹：
Anti-CDKN2A/p19ARF抗體產(chǎn)品質(zhì)量穩(wěn)定，實(shí)驗(yàn)效果明顯，貨期快，價(jià)格優(yōu)惠，歡迎垂詢訂購！我公司長期供應(yīng)**組化抗體、WB抗體、**組化試劑盒和抗體試驗(yàn)所需全部相關(guān)試劑、熒光標(biāo)記抗體、單克隆抗體、多克隆抗體、各種標(biāo)記的二抗IgG/IgM/IgD/IgA等科研實(shí)驗(yàn)抗體。Anti-CDKN2A/p19ARF抗體用于**組化實(shí)驗(yàn),WB實(shí)驗(yàn),相應(yīng)的標(biāo)記抗體有HRP標(biāo)記抗體,FITC標(biāo)記,BIO等。
詳情介紹：
Rabbit Anti-CDKN2A/p19ARF
Cat. Number:
Anti-CDKN2A/p19ARF抗體KL-0534R
Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic Anti-CDKN2A/p19ARF抗體action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
Also known as:
MTS1; ARF; CDK4 inhibitorAnti-CDKN2A/p19ARF抗體 P16 INK4; CDKN2A; Cyclin dependent kinase inhibitor 2A; INK4; P19; P19ARF; p19INK4a.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, .
●
Immunogen: KLH conjugated synthetic peptide derived from human P19ARF.
●
Predicted Molecular Weight: Anti-CDKN2A/p19ARF抗體19kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions Anti-CDKN2A/p19ARF抗體must be determined by the end user.
Not yet tested in other applications.
Optimal working dilutions Anti-CDKN2A/p19ARF抗體must be determined by the end user.
kl885Hu01 血清淀粉樣蛋白A(SAA)多克隆抗體 Polyclonal Antibody to Serum Amyloid A (SAA)
kl885Mu01 血清淀粉樣蛋白A(SAA)多克隆抗體 Polyclonal Antibody to Serum Amyloid A (SAA)
kl885Rb52 血清淀粉樣蛋白A(SAA)多克隆抗體 Polyclonal Antibody to Serum Amyloid A (SAA)
kl886Bo01 過氧化物酶體增殖物激活受體γ(Pklγ)多克隆抗體 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (Pklg)
kl886Hu01 過氧化物酶體增殖物激活受體γ(Pklγ)多克隆抗體 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (Pklg)
kl886Mu01 過氧化物酶體增殖物激活受體γ(Pklγ)多克隆抗體 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (Pklg)
kl886Ra01 過氧化物酶體增殖物激活受體γ(Pklγ)多克隆抗體 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (Pklg)
kl887Hu01 丙酮酸脫氫酶磷酸酶(PDP)多克隆抗體 Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP)
kl887Mu01 丙酮酸脫氫酶磷酸酶(PDP)多克隆抗體 Polyclonal Antibody to Pyruvate Dehydrogenase Phosphatase (PDP)
kl888Hu01 補(bǔ)體成分4(C4)多克隆抗體 Polyclonal Antibody to Complement Component 4 (C4)
kl888Mu01 補(bǔ)體成分4(C4)多克隆抗體 Polyclonal Antibody to Complement Component 4 (C4)
kl888Ra01 補(bǔ)體成分4(C4)多克隆抗體 Polyclonal Antibody to Complement Component 4 (C4)
kl889Ca01 腎素(REN)多克隆抗體 Polyclonal Antibody to Renin (REN)
